Isotopically Labeled Compounds
Medchemexpress LLC Tacrolimus-13C,d2 | 1356841-89-8 | 98.4% | 807.02 | 1 MG
Tacrolimus-13C,d2 is a 13C-labeled and deuterium-labeled form of Tacrolimus, a macrocyclic lactone. It inhibits calcineurin phosphatase by forming a complex with FKBP, which leads to immunosuppressive properties by inhibiting T-lymphocyte signal transduction and IL-2 transcription. This compound can be used as a tracer and an internal standard for quantitative analysis.
- Labeled with 13C and deuterium
- Inhibits calcineurin phosphatase
- Possesses immunosuppressive properties
- Can be used as a tracer
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
Medchemexpress LLC Moxidectin-d3 | 113507-06-5 | 95.2% | 1 MG
Moxidectin-d3 (CL-301423-d3) is a deuterium-labeled version of Moxidectin. Moxidectin is an orally active macrolide (ML) anthelmintic used for the prevention and control of heartworms and roundworms. It is also a substrate of BCRP and P-glycoprotein (P-gp) in vivo, and is secreted into breast milk and effluxed from the host and parasite by Bcrp1 and P-gp.
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
- Stable heavy isotopes of hydrogen, carbon, and other elements are incorporated into drug molecules.
- Deuteration has the potential to influence the pharmacokinetic and metabolic profiles of drugs.
Medchemexpress LLC Nitrendipine-d5 | 2469554-26-3 | 99.8% | 1 MG
Nitrendipine-d5 is a deuterium-labeled version of Nitrendipine, an orally active analog of Nifedipine that functions as a dihydropyridine calcium channel blocker. It has been shown to induce apoptosis and possess antihypertensive effects. Additionally, it can block alcohol and morphine withdrawal symptoms, reduce right ventricular hypertrophy, and alleviate pulmonary vascular changes caused by intermittent hypoxia. It also exhibits anticancer effects on neuroblastoma.
- Application as a tracer
- Internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
- Deuteration can influence the pharmacokinetic and metabolic profiles of drugs
Medchemexpress LLC Dinotefuran-d3 | 2934813-27-9 | 98.71% | 1 MG
Dinotefuran-d3 is a deuterium-labeled variant of Dinotefuran, an insecticide belonging to the neonicotinoid class. Its primary mode of action is to disrupt the insect's nervous system by inhibiting nicotinic acetylcholine receptors. This product is exclusively for research purposes and is not for sale to patients.
- Serves as a tracer for quantitation during drug development.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
- Deuterium substitution may influence the pharmacokinetic and metabolic profiles of drugs.
Medchemexpress LLC Diethyltoluamide-d7 | 1219799-37-7 | 98.5% | 1 MG
Diethyltoluamide-d7 is the deuterium labeled Diethyltoluamide. It is the most common active ingredient in insect repellents, providing protection against mosquitoes, ticks, fleas, chiggers, leeches, and many other biting insects. This product is for research use only.
- Deuterium labeled
- Can be used as a tracer
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
Medchemexpress LLC Nateglinide-d5 | 1227666-13-8 | 98.0% | 5 MG
Nateglinide-d5 is a deuterium-labeled derivative of Nateglinide, a D-phenylalanine derivative. Nateglinide acts as an orally active and short-acting insulinotropic agent and a DPP IV inhibitor. It inhibits ATP-sensitive K+ channels in pancreatic β-cells and is used in the treatment of type 2 (non-insulin-dependent) diabetes mellitus.
- Can be used as a tracer
- Functions as an internal standard for quantitative analysis methods such as NMR, GC-MS, or LC-MS
Medchemexpress LLC Pentoxifylline-d6 | 1185878-98-1 | 99.0% | 5 MG
Pentoxifylline-d6 | 1185878-98-1 | 99.0% | 5 MG
Medchemexpress LLC Triamterene-d5 | 1189922-23-3 | 99.8% | 1 MG
Triamterene-d5 is a deuterium-labeled form of Triamterene, which functions by blocking the epithelial Na+ channel (ENaC) in a voltage-dependent manner, acting as a mild diuretic. It also serves as an inhibitor of the TGR5 receptor. This compound is intended for research use only and is not for sale to patients.
- Deuterium-labeled compound
- Can be used as a tracer
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
- Blocks epithelial Na+ channel (ENaC)
- Acts as a mild diuretic
- Inhibitor of the TGR5 receptor
Medchemexpress LLC Homosalate-d4 (Homomenthyl salicylate-d4) | 118-56-9 | 99.95% | 5 MG
Homosalate-d4 is the deuterium labeled Homosalate, an organic compound used in sunscreens as a chemical UV filter to protect the skin from sun damage. Intended for research use only, this compound can serve as a tracer and an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS. Stable heavy isotopes, like deuterium, are incorporated into drug molecules for quantitation during drug development, with deuteration showing potential to influence the pharmacokinetic and metabolic profiles of drugs.
- Can be used as a tracer
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
Medchemexpress LLC Permethrin-d9 | 52645-53-1 | 98.2% | 1 MG
Permethrin-d9 is a deuterium-labeled version of Permethrin, an insecticide, acaricide, and insect repellent. It functions as a neurotoxin by affecting neuron membranes through prolonging sodium channel activation. This compound is for research use only and can be utilized as a tracer or an internal standard for quantitative analysis.
- Deuterium-labeled Permethrin
- Functions as an insecticide, acaricide, and insect repellent
- Acts as a neurotoxin by prolonging sodium channel activation
- Can be used as a tracer
- Can be used as an internal standard for quantitative analysis (NMR, GC-MS, LC-MS)
- Deuteration can influence pharmacokinetic and metabolic profiles
Medchemexpress LLC Nafcillin-d5 sodium | 1356354-25-0 | 97.8% | 1 MG
Nafcillin-d5 (sodium) is the deuterium labeled Nafcillin sodium. Nafcillin sodium, an antibiotic, is a reversible inhibitor of β-lactamase and can be used for the research of staphylococcal infections.
- This compound can be used as a tracer.
- This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Medchemexpress LLC Nabumetone-d3 (BRL14777-d3) | 1216770-08-9 | 98.8% | 1 MG
Nabumetone-d3 is the deuterium-labeled form of Nabumetone (HY-B0559), an orally active, non-acidic anti-inflammatory agent. It acts as a potent and selective COX-2 inhibitor and is a proagent for its active metabolite, α-Demethylnaproxen (HY-W086896). Nabumetone has been observed to inhibit cancer cell proliferation and reduce gastric ulcers. This compound is intended for research applications, such as a tracer or an internal standard in quantitative analyses like NMR, GC-MS, or LC-MS.
- Deuterium-labeled form of nabumetone.
- Orally active, non-acidic anti-inflammatory agent.
- Potent and selective COX-2 inhibitor.
- Proagent for its active metabolite.
- Inhibits cancer cell proliferation.
- Reduces gastric ulcers.
- Intended for research applications.
- Suitable as a tracer or internal standard in quantitative analyses like NMR, GC-MS, or LC-MS.
Medchemexpress LLC Latanoprost-d4 | 130209-82-4 | 98.0% | 500 UG
Latanoprost-d4 is the deuterium-labeled Latanoprost, a prostaglandin F2α analogue and an agonist for the FP prostanoid receptor, which lowers intraocular pressure (IOP). It serves as a tracer and an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS. Deuteration has the potential to affect the pharmacokinetic and metabolic profiles of drugs, offering valuable insights in research.
- Deuterium labeled compound
- Prostaglandin F2α analogue
- Agonist for FP prostanoid receptor
- Lowers intraocular pressure (IOP)
- Useful as a tracer
- Functions as an internal standard for quantitative analysis
- Can affect pharmacokinetic and metabolic profiles of drugs